Digital Brain Laboratory

Multi-scale, full-stack, brain simulation.

Building a computable brain across molecules, cells, circuits, and the whole brain.

Research Directions

01 / 03

Foundational Brain-Simulation Software

Multi-scale modeling toolchain — from single cells and circuits to whole-brain networks.

Explore the toolchain →

02 / 03

Brain-Simulation Modeling Algorithms

Data- and task-driven multi-scale modeling for brain dynamics.

Explore the algorithms →

03 / 03

Large-Scale Computational Brain Models

Cross-scale dynamics across molecules, cells, circuits, and systems.

Explore the models →
Software the field uses
BrainPy
A general programming framework for brain dynamics modeling.
pip install brainpy
→
BrainTrace
Online learning compiler for brain dynamics based on eligibility traces.
pip install braintrace
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BrainUnit
Physical units and unit-aware mathematics system for brain dynamics.
pip install brainunit
→
BrainState
State-transformation and high-efficiency simulation across CPUs, GPUs, and TPUs.
pip install brainstate
→
Recent publications All publications →
  • 2026 Nature Communications

    Model-agnostic linear-memory online learning in spiking neural networks

    Chaoming Wang, Xingsi Dong, Zilong Ji, Mingqing Xiao, Jiedong Jiang, Xiao Liu, Yuxiang Huan, Si Wu

    DOI ↗
  • 2025 Nature Communications

    Integrating physical units into high-performance AI-driven scientific computing

    Chaoming Wang, Sichao He, Shouwei Luo, Yuxiang Huan, Si Wu

    DOI ↗
  • 2024 Nature Communications

    High-order sensory processing nanocircuit based on coupled VO2 oscillators

    Ke Yang, Yanghao Wang, Pek Jun Tiw, Chaoming Wang, Xiaolong Zou, Rui Yuan, Chang Liu, Ge Li, Chen Ge, Si Wu, Teng Zhang, Ru Huang, Yuchao Yang

    DOI ↗
  • 2024 Cell Reports

    Spindle oscillations emerge at the critical state of electrically coupled networks in the thalamic reticular nucleus

    Shangyang Li, Chaoming Wang, Si Wu

    DOI ↗
  • 2023 eLife

    BrainPy, a flexible, integrative, efficient, and extensible framework for general-purpose brain dynamics programming

    Chaoming Wang, Tianqiu Zhang, Xiaoyu Chen, Sichao He, Shangyang Li, Si Wu

    DOI ↗